Perinatal ProgrammingDeborah Hodgson, Christopher Coe CRC Press, 2005 M12 20 - 352 pages Perinatal factors are critical in the 'programming' of behavioral, endocrine and immunologic outcomes of adult life. Exposure to many factors in utero can drive fetal development along specific trajectories. Perinatal factors can also affect many diverse systems that have significant implications for long-term health outcomes. The findings from basic research are so diverse and suggest implications in many different arenas. Bringing together these findings, this book explores the evidence linking the role of early life events to long-term physical and psychological health outcomes. It pulls the research together and communicates the findings to the wider scientific and clinical communities. |
Contents
Maternal nutrition and later disease risk | 17 |
PRENATAL PROGRAMMING OF THE NEUROENDOCRINE SYSTEM LINKS | 47 |
Prenatal programming of postnatal obesity | 73 |
Development of domestic animal models for the study of the ontogeny of human disease | 117 |
EARLY LIFE PROGRAMMING OF IMMUNITY LINKS TO INFECTIOUS | 129 |
Role of prenatal events in the development of allergic disease | 143 |
Perinatal characteristics and asthma and allergies in offspring | 155 |
Maternal alcohol consumption and neuroendocrineimmune interactions in the offspring | 169 |
Pain sensitivity during ontogeny and longterm effects of prenatal noxious events | 211 |
PERINATAL FACTORS ALTERING BEHAVIORAL OUTCOMES | 223 |
The role of prenatal stress in the programming of behavior | 241 |
links with maternal stress | 253 |
an empirical and theoretical integration | 267 |
PRE AND POSTNATAL MODULATION OF | 287 |
Maternal programming of glucocorticoid receptor expression and HPA responses to stress | 309 |
| 325 | |
how early contact with certain microorganisms may influence | 183 |
EARLY LIFE PROGRAMMING OF PAIN RESPONSIVENESS | 195 |
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activity adrenal adult alcohol Allergy altered androgen animals antenatal anxiety associated asthma atopy behavior beta cell Brain Res childhood Clin Endocrinol Metab clinical corticosterone cortisol cytokines decreased demethylation developmental dexamethasone diabetes diet differences disease disorders DNA methylation early effects of prenatal endocrine environment environmental epigenetic exon exposure expression females fetal growth fetus function gene genetic gestational age glucocorticoid receptor glucose hippocampal histone hormones HPA axis human hypertension IGF-I immune responses immune system Immunol impaired imprinting increased induced infants infection influence insulin resistance intrauterine islet leptin levels long-term low birth weight lung male maternal stress mechanisms mediated metabolic monkeys mRNA neonatal neuroendocrine neurons Neurosci NGFI-A nutrients nutrition obesity Obstet Gynecol offspring outcomes pain pancreatic pathways Pediatr perinatal Physiol pigs placental plasma postnatal pregnancy prenatal stress preterm programming protein rats reduced regulation risk role sensitivity studies suggest tion tissue transcription undernutrition utero