Adverse Effects of Pertussis and Rubella VaccinesInstitute of Medicine, Committee to Review the Adverse Consequences of Pertussis and RubellaVaccines National Academies Press, 1991 M01 1 - 382 pages Parents have come to depend on vaccines to protect their children from a variety of diseases. Some evidence suggests, however, that vaccination against pertussis (whooping cough) and rubella (German measles) is, in a small number of cases, associated with increased risk of serious illness. This book examines the controversy over the evidence and offers a comprehensively documented assessment of the risk of illness following immunization with vaccines against pertussis and rubella. Based on extensive review of the evidence from epidemiologic studies, case histories, studies in animals, and other sources of information, the book examines:
The volume, which includes a description of the committee's methods for evaluating evidence and directions for future research, will be important reading for public health officials, pediatricians, researchers, and concerned parents. |
Contents
Executive Summary 1 | |
Histories of Pertussis and Rubella Vaccines 9 | |
Methodologic Considerations in Evaluating the Evidence 32 | |
Evidence Concerning Pertussis Vaccines and Central Nervous 65 | |
Evidence Concerning Pertussis Vaccines and Deaths Classified as Sudden Infant Death Syndrome SIDS | |
Evidence Concerning Pertussis Vaccines and Other Illnesses and 144 | |
Learning Disabilities and Hyperactivity 161 | |
Reye Syndrome 169 | |
Thrombocytopenia 177 | |
Evidence Concerning Rubella Vaccines and Arthritis Radicu loneuritis and Thrombocytopenic Purpura 187 | |
Adverse Effects of Per tussis and Rubella Vaccines 293 | |
Animal Models for the Study of Whooping Cough and the Testing of Vaccine Materials 333 | |
E Possible Involvement of Aluminum Salts in Erythema Multi forme Encephalopathy or Other Adverse Events After 347 | |