Prokaryotic Gene ExpressionSimon Baumberg OUP Oxford, 1999 M05 27 - 346 pages Prokaryotic gene expression is not only of theoretical interest but also of highly practical significance. It has implications for other biological problems, such as developmental biology and cancer, brings insights into genetic engineering and expression systems, and has consequences for important aspects of applied research. For example, the molecular basis of bacterial pathogenicity has implications for new antibiotics and in crop development. Prokaryotic Gene Expression is a major review of the subject, providing up-to-date coverage as well as numerous insights by the prestigious authors. Topics covered include operons; protein recognition of sequence specific DNA- and RNA-binding sites; promoters; sigma factors, and variant tRNA polymerases; repressors and activators; post-transcriptional control and attenuation; ribonuclease activity, mRNA stability, and translational repression; prokaryotic DNA topology, topoisomerases, and gene expression; regulatory networks, regulatory cascades and signal transduction; phosphotransfer reactions; switch systems, transcriptional and translational modulation, methylation, and recombination mechanisms; pathogenicity, toxin regulation and virulence determinants; sporulation and genetic regulation of antibiotic production; origins of regulatory molecules, selective pressures and evolution of prokaryotic regulatory mechanisms systems. Over 1100 references to the primary literature are cited. Prokaryotic Gene Expression is a comprehensive and authoritative review of current knowledge and research in the area. It is essential reading for postgraduates and researchers in the field. Advanced undergraduates in biochemistry, molecular biology, and microbiology will also find this book useful. |
Contents
Regulation via alternative o factors | 7 |
Concluding remarks | 13 |
Examples of proteinnucleic acid complexes | 33 |
Postscript | 52 |
Promoters sigma factors and variant | 59 |
Alternative o factors and their roles | 74 |
Repressors and activators | 92 |
Control of transcription factor activity | 98 |
Twocomponent systems | 194 |
Switch systems | 229 |
Phase switching by DNA inversion | 237 |
Variation by homologous recombination | 243 |
Integration of control devices I Pathogenicity | 253 |
Pleiotropic regulators of gene expression and virulence in Salmonella | 258 |
Control of virulence gene expression in Bordetella pertussis | 265 |
Host cell contact and virulence gene expression | 271 |
Simple repression | 105 |
Posttranscriptional control | 115 |
Prokaryotic DNA topology and gene expression | 141 |
Effects of transcription on supercoiling | 147 |
A global regulatory | 169 |
Connections between the responses to stationary phase high | 180 |
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Common terms and phrases
Acad amino acid antibiotic attenuation Bacillus subtilis bacterial Bacteriol bacteriophage base pairs bending binding Biochem Biol biosynthesis cell cellular Chem chromosome codon coli RNA polymerase contacts dimer DNA supercoiling DNA topology DNA-binding EMBO environmental enzyme Escherichia coli flexneri formation function gene encoding gene expression genetic growth gyrase H-NS heat shock histidine HPK domain induced interactions intracellular involved loop mechanism Microbiol modulate molecular molecules motif mRNA mutants N-terminal Natl Neisseria Ninfa NRII nucleotide OmpR operator operon pathogenic peptide phage phosphatase phosphate phosphorylation plasmid Proc prokaryotic promoter recognition recombination region regulatory protein regulon repression repressor response regulator ribosome RNA polymerase RNAP role rpoS RR domain RR~P Salmonella typhimurium sequence sigma factor signal transduction Silhavy specific spore sporulation stationary phase structure subunit synthesis target topoisomerase transcription initiation transcriptional activator translation tRNA upstream virulence gene vitro vivo
References to this book
An Introduction to Systems Biology: Design Principles of Biological Circuits Uri Alon No preview available - 2006 |